McMaster University

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Chiko Shimbori

Chiko Shimbori

Current standing:

  • Post Doctoral Fellow (since June 2012)
  • Firestone Institute for Respiratory Health, McMaster University
  • Assistant Professor (since April 2006)
  • Department of Pharmacology, Shimane University School of Medicine


  • PhD in Medicine, Shimane University, School of Medicine (Japan), March 2011

Research Interests:

I am interested in the profibrotic microenvironment in pulmonary fibrosis.  I am working on multilateral projects to reveal the pathogenesis of pulmonary fibrosis in Dr.Kolb Lab using many types of pulmonary fibrosis animal models.


  • The role of epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) response in pulmonary fibrosis
  • Mechanical stretch and pulmonary fibrosis
  • The role of mast cells in pulmonary fibrosis



Recent publications:

  • Shimbori C, Gauldie J, Kolb M. Extracellular Matrix Microenvironment Contributes Actively toPulmonary Fibrosis. Current Opinion in Pulmonary Medicine. In Press.

Recent Abstracts:

  • Shimbori C, Liu TY, Gauldie J, Ramos C, Selman M, Kolb M. Fibroblast Growth Factor-1 ameliorates TGF-beta1-induced lung dysfunction and pulmonary fibrosis. ATS 2013

Selected Previous Publications:

  1. Shimbori C, Shiota N, Okunishi H. Pranlukast, a cysteinyl leukotriene type 1 receptor antagonist, attenuates the progression, but not the onset, of silica-induced pulmonary fibrosis in mice. Int Arch Allergy Immunol. 158:241-251, 2011.
  2. Shimbori C, Shiota N, Okunishi H. Effects of montelukast, a cysteinyl-leukotriene type 1 receptor antagonist, on the pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Eur J Pharmacol. 650: 424-430. 2011.
  3. Shimbori C, Shiota N, Okunishi H. Involvement of leukotrienes in the pathogenesis of silica-induced pulmonary fibrosis in mice. Exp Lung Res. 36: 292-301, 2010
  4. Shiota N, Kovanen PT, Eklund EE, Shibata N, Shimoura K, Niibayashi T, Shimbori C, Okunishi H. The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice. British Journal of Pharmacology. 159: 626-635, 2010.
  5. Shiota N, Nishikori Y, Kakizoe E, Shimoura K, Niibayashi T, Shimbori C, Tanaka T, Okunishi H. Pathophysiological Role of Skin Mast Cells in Wound Healing after Scald Injury: Study with Mast Cell-Deficient W/WV Mice. International Archives of Allergy and Immunology. 151: 80-88, 2009.


  • Grant-in-Aid for Young Scientists (B) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (2010-2011).